The Rubik's Cube was the main character of the Annoying Orange episode of the same name. He or she was seen being annoyed by Orange in all 6 of its phases.
Phases
Red Side
Rubik's Cube's red side
Rubik's Cube first appeared after Orange asked who he was. Apparently, Orange had made a pun about squares, and this offended him, making him say that he was a cube and not a square. Orange continued to annoy him in other means, such as insulting his name by saying "Gesundheit" each time he stated his name. He later grew obstreperous and impatient after Orange called him a doofus and decided to switch sides.
Green Side
Rubik's Cube's green side
After Rubik's Cube switched to his green side, he complained to Orange that he had to stop frustrating Red with his constant annoyances. However, Orange neglected to heed his warning and continued making jokes anyway. Green became confused at Orange's "gesundheit" joke but was still insulted after Orange mistook his name for "Susie Q." He also grew obstreperous and impatient of Orange and switched sides again.
White Side
Rubik's Cube's white side
Rubik's Cube then switched to his white side. He made a short appearance looking dazed because he was about to literally sneeze. Orange was confused as to why he was doing this, but kept making jokes despite this. After he sneezed, Orange said "gesundheit" as usual, making this side a joke filler for a joke filler. He then switched sides again despite that White was not annoyed by Orange at all.
Blue Side
Rubik's Cube's blue side
Rubik's Cube switched to his blue side next. Blue was not fond of Orange's jokes at all, and was actually very calculating, manipulative, pessimistic, suspicious, and sarcastic around Orange. He then remarked that he was surprised at how Orange didn't resort to smurf jokes yet. Like Red and Green, Blue left abruptly with a final comment of frustration and disrespect. He was followed by the yellow side. He spoke in German dialect.
Yellow Side
Rubik's Cube's yellow side
Yellow arrived under a positive note, but was almost immediately offended by Orange's chicken pun. Like many of the other sides, she was also confused at Orange's "gesundheit" joke. She was able to acknowledge Orange's abusive, rude, annoying, vituperative, and obnoxious antics and pondered why nobody thought of it sooner. She was replying this way before she switched to her orange side played by the YouTube sensation Colleen Ballinger
Orange Side
Rubik's Cube's orange side
Orange arrived as the final side of the cube. He was seen making jokes and laughing the same way that Orange does on a normal daily basis, (except he talks fast) and was proven to be as annoying as Orange. Coincidentally, he is the same color as Orange, and is also as annoying. Pear was very annoyed and frustrated by this, and was trying to warn him about a hand, which proceeded to twist up the Rubik's Cube. Pear made a joke after this, but Orange hypocritically told Pear it was "too soon!" After this, all sides of the Rubik's Cube were integrated.